Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO-Public Health), Infection and Health unit, Valencia, Spain.
Antimicrobial resistant (AMR) Neisseria gonorrhoeae is an urgent threat to public health as strains resistant to at least one of the two last line antibiotics used in empiric therapy of gonorrhoea, ceftriaxone and azithromycin, have spread internationally and new treatment options are not yet available. This is compromising the control of gonorrhoea infections, which led to an international call for collaborative action on global surveillance for this sexually-transmitted pathogen. Whole-genome sequencing (WGS) has revolutionized the study of infectious diseases, allowing to track the spread of N. gonorrhoeae and other bacterial pathogens and especially AMR lineages, with an utmost resolution. With the appropriate bioinformatic methods, high throughput sequencing data can be processed to extract typing and AMR information simultaneously, while at the same time informing on new high-risk clones, outbreaks, transmission chains and the development of point-of-care tests. The use of WGS has provided further insight into how N. gonorrhoeae spreads in different sexual networks. A recent genomic study revealed particular lineages associated to different risk populations and with different antimicrobial susceptibilities. Results showed two major lineages, which may represent two epidemiological strategies used by N. gonorrhoeae. Interestingly, genomic data from other studies have found the same pattern in different collections. In this talk, I will review how genomics can lead new breakthroughs in the current knowledge of gonorrhoea infections, and how it can be used to inform on antibiotic treatment, disease prevention and control.
34 IUSTI Congress - European Congres on Sexually transmitted Infections and HIV/AIDS
TAMING THE TIDE of STIs & HIV
Bucharest, September 3-5,