Abstract



HIV / AIDS ALONE AND IN ASSOCIATION WITH TB; IMPLICATIONS IN DISEASE EVOLUTION AND ANTIRETROVIRAL THERAPY

Dana Gabriela Negru, Emilian Damian Popovici, Ioana Rucsanda Toma, Victor Toma, Iustin Olariu

Epidemiology Medical Office Dr. Negru Dana, Arad

Victor Babes University of Medicine and Pharmacy Timisoara

Victor Babes University of Medicine and Pharmacy Timisoara

County Emergency Clinical Hospital „Pius Brînzeu” Timișoara

Vasile Goldis Western University of Arad

Objectives. HIV/AIDS infection has the tendency to many complications due to immunosuppression (which makes that other co-infections to occur easily), viral resistance to antiretroviral therapy (which makes it necessary to change antiretroviral treatment regimens) and due to the adverse effects of antiretroviral therapy itself (especially in the case of Protease inhibitors). The objectives of the paper are: determining the frequency of associated viral and bacterial infections (tuberculosis, hepatitis B and C virus, syphilis, etc.) and assessing the mobility of treatment regimens, depending on viral load and immune status of the patient, reflected by decreased CD4 lymphocyte subpopulation.

Methods. Biological parameters (CD4 lymphocytes) and the viral load of the 200 enlisted patients in 2020, in Arad County database, in addition to the prescribed treatment regimens, including adherence to treatment, were analyzed to assess the clinical evolution. All data have been processed using IBM SPSS Statistic 20 and MedCalc software packages.

Results. There are 200 HIV/AIDS recorded patients in Arad County, with gender ratio of M: F= 2.03:1. Survival rates over 10 to 24 years, is more common in women compared to men (P= 0.048). TB infection rates are 17.21% for men (n=21) and 11.66% for women (n=7), with no statistical significance for gender Odds ratio(P = 0.3325). Generally, every two years there is a different therapy regimen for most of the patients, and there are patients who have already a history of 10 treatment regimens. In term of Protease inhibitors (PIs), a number of 133 patients have had them alone or associated with Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs), Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs), Integrase Inhibitors (II) and Fusion Inhibitors(FI).

Conclusion. The fact that there is a high mobility of antiretroviral regimens related to viral load and to the immune response of CD4, shows indirectly that there is an important rate of viral resistance to antiretroviral therapy (HIVDR), even in the absence of demonstrated mutations by next-generation sequencing (NGS) technology. The ability of HIV / AIDS viruses to develop mutations is well known. HIVDR can induce treatment failure, decreases the chance of the patient to become non-infectious, and last but not least, has the effect of compromising the effectiveness of the limited therapeutic options.


64|dananegruarad@yahoo.com|W1-3
34 IUSTI Congress - European Congres on Sexually transmitted Infections and HIV/AIDS
TAMING THE TIDE of STIs & HIV
Bucharest, September 3-5,