Abstract



CHALLENGES IN RAPID MOLECULAR TESTING FOR DETERMINING ANTIMICROBIAL RESISTANCE IN NEISSERIA GONORRHOEAE

Jo-Anne R Dillon1,2, Sumudu R Perera1,2, Nidhi R Parmar1,2, Reema Singh1,2

1. Department of Biochemistry, Microbiology and Immunology, College of Medicine

2. Vaccine and Infections Disease Organization – International Vaccine Centre

University of Saskatchewan

Saskatoon, SK, Canada  

 

Neisseria gonorrhoeae has developed resistance to every antibiotic recommended for therapy. Antimicrobial susceptibility testing is a key public health strategy in ensuring that effective antibiotics are used to treat infections caused by N. gonorrhoeae. This testing requires that the organism be cultured fist - often unachievable in resource-challenged settings or areas in which nucleic acid amplification tests are used for diagnosis. Thus, there is an urgent need for rapid molecular diagnostic strategies to ascertain the antimicrobial susceptibility of N. gonorrhoeae isolates, guide treatment and ensure effective antimicrobial stewardship. This talk will review the challenges inherent in the development of such tests. These challenges include the continuing emergence of novel resistance determinants in N. gonorrhoeae, the requirement to ascertain the genotypes of multiple genes for some antibiotics to establish a susceptibility/resistance phenotypes, and the current limitations of genomic strategies to provide resistance-guided treatment.


87|j.dillon@usask.ca|S3-8
34 IUSTI Congress - European Congres on Sexually transmitted Infections and HIV/AIDS
TAMING THE TIDE of STIs & HIV
Bucharest, September 3-5,